Marvel’s Spider-Man 2 had a tall order in delivering fun villains after the original game had already debuted the Sinister Six, which included Doctor Octopus, Mr. Negative, Electro, Vulture, Scorpion, and Rhino.

Source: https://gamerant.com/marvels-spider-man-2-sandman-villain-tutorial-boss-side-quest/

Sony's canceled Sinister Six film would have featured Spider-Man riding a T-Rex in the Savage Land, a prehistoric area hidden in Antarctica.

Source: https://gamerant.com/spiderman-sinister-six-movie-t-rex-savage-land/

The fact that the Sinister Six has already been confirmed to exist on Earth-42 in Spider-Man: Across the Spider-Verse answers some major questions concerning the ending of the 2023 film.

Source: https://screenrant.com/spiderman-across-spiderverse-behind-scene-villain-sinister-six-3-fight/

"The Marvel Sinister Six series sets a whole new scene in your collection and it is exclusively available here.

Source: https://comicbook.com/marvel/news/sinister-6-funko-pops-spiderman-beyond-amazing-deal/